Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8586269 | 0.88 | MTNR1A (0.61) | TAAR1ADRA1AHTR2AMEN1KMT2A | |
| SCHEMBL5541597 | 0.86 | MTNR1A (0.49) | HTR2AKMT2AMAPTTSHRMTNR1A | |
| SCHEMBL10663900 | 0.82 | MTNR1A (0.55) | HTR2AHTR6MAPTMTNR1AMTNR1B | |
| SCHEMBL10470119 | 0.82 | MTNR1A (0.52) | HTR2AMEN1KMT2AMAPTMTNR1A | |
| SCHEMBL6839987 | 0.81 | CYP2A6 (0.53) | MAPTTSHRMTNR1AMTNR1BNPSR1 | |
| SCHEMBL5439262 | 0.81 | MTNR1A (0.44) | MAPTTSHRMTNR1AMTNR1BNPSR1 | |
| SCHEMBL5544113 | 0.81 | MTNR1A (0.51) | HTR2AMEN1KMT2AMAPTMTNR1A | |
| SCHEMBL5211436 | 0.81 | PPARG (0.46) | MEN1KMT2AHTR1AMTNR1AMTNR1B | |
| SCHEMBL8021641 | 0.79 | MTNR1A (0.59) | TAAR1ADRA1AHTR2AMEN1KMT2A | |
| SCHEMBL10663910 | 0.79 | HTR2A (0.55) | TAAR1HTR2AHTR1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027984-A1 | METHOD OF PRODUCING ANALGESIA BY ADMINISTRATION OF 1,2,3,4-TETRAHYDROBENZO-[b]THIENO[2,3-c]PYRIDINE AND DERIVATIVES | NEUREX CORPORATION (US) | 1998-07-02 | — | — | WO | disclosed |
| US-4971974-A | ANOREXIGENIC AGENTS, BENZO B!THIENO 2,3-C!PYRIDINE COMPOUNDS | NEUREX CORPORATION (US) | 1990-11-20 | — | — | US | disclosed |
| US-4764506-A | IMMUNOINFLAMMATION | WARNER-LAMBERT COMPANY (US) | 1988-08-16 | — | — | US | disclosed |
| US-4636493-A | HYPOTENSIVES | WARNER-LAMBERT COMPANY (US) | 1987-01-13 | — | — | US | disclosed |
| US-4600707-A | ANTIPSYCHOTIC AGENTS, HYPOTENSIVES | WARNER-LAMBERT COMPANY (US) | 1986-07-15 | — | — | US | disclosed |