Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.53 |
| ▸ | CTSS | P25774 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 2/20 | 0.50 |
| ▸ | SSTR3 | P32745 | 2/20 | 0.48 |
| ▸ | TACR1 | P25103 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SSTR2 | P30874 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | P4HB | P07237 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.44 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.44 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27621167 | 1.00 | CTSL (0.53) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL8528011 | 1.00 | CTSL (0.53) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL5913306 | 1.00 | CTSL (0.53) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL11636711 | 0.84 | CTSL (0.53) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL30873796 | 0.84 | CTSL (0.53) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL8700164 | 0.83 | ALOX15 (0.48) | MAPTACETACR1MEN1KMT2A | |
| SCHEMBL8711954 | 0.83 | ALOX15 (0.48) | MAPTACETACR1MEN1KMT2A | |
| SCHEMBL5913553 | 0.82 | SSTR2 (0.50) | SSTR3KMT2ASSTR2SSTR1SSTR4 | |
| SCHEMBL8897369 | 0.82 | MAPT (0.51) | CTSLCTSSCTSKMAPTTP53 | |
| SCHEMBL8068441 | 0.82 | NMBR (0.58) | MAPTTACR1SMN1; SMN2SSTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6063796-A | HETEROCYCLIC COMPOUNDS OF PIPERIDINE | MERCK & CO., INC. (US) | 2000-05-16 | — | — | US | disclosed |
| EP-0984779-A4 | SOMATOSTATIN AGONISTS | MERCK & CO INC (US) | 2000-05-10 | — | — | EP | disclosed |
| EP-0984779-A1 | SOMATOSTATIN AGONISTS | Merck & Co., Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998044922-A1 | SOMATOSTATIN AGONISTS | MERCK & CO., INC. (US) | 1998-10-15 | — | — | WO | disclosed |
| US-5804578-A | USEFUL FOR TREATING OSTEOPROSIS, CATABOLIC ILLNESS, IMMUNE DEFICIENCY, BONE FRACTURE, SHROT STATURE IN CHILDREN, OBASITY, SLEEP DISORDER, CACHEXIA AND PROTEIN LOSS DUE TO CHRONIC ILLNESS SUCH AS AIDS AND CANCER | MERCK & CO., INC. (US) | 1998-09-08 | — | — | US | disclosed |
| US-5721251-A | INCREASING SECRETION OF GROWTH HORMONE IN HUMANS AND ANIMALS | MERCK & CO., INC. (US) | 1998-02-24 | — | — | US | disclosed |