SCHEMBL8023079

SCHEMBL8023079

COc1ccc(C(Cl)=CC(=O)C=C(Cl)c2ccc(OC)cc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.55
CES1 P23141 2/20 0.55
CA1 P00915 5/20 0.53
CA2 P00918 5/20 0.53
PARP1 P09874 1/20 0.52
PARP10 Q53GL7 1/20 0.52
PARP2 Q9UGN5 1/20 0.52
PARP4 Q9UKK3 1/20 0.52
HPGD P15428 2/20 0.52
TCF4 P15884 1/20 0.51
CTNNB1 P35222 1/20 0.51
CYP2C19 P33261 2/20 0.50
MAPK1 P28482 2/20 0.50
HSD17B10 Q99714 2/20 0.50
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.50
LMNA P02545 1/20 0.50
ESR1 P03372 1/20 0.50
ADORA3 P0DMS8 1/20 0.50
MAPT P10636 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6656342 0.87 CA1 (0.57) CES2CES1CA1CA2PARP1
SCHEMBL6656346 0.87 CA1 (0.57) CES2CES1CA1CA2PARP1
SCHEMBL6656347 0.87 CA1 (0.57) CES2CES1CA1CA2PARP1
SCHEMBL28858524 0.82 CES2 (0.56) CES2CES1CA1CA2PARP1
SCHEMBL28858520 0.82 CES2 (0.56) CES2CES1CA1CA2PARP1
SCHEMBL28427034 0.81 CES2 (0.59) CES2CES1CA1CA2CYP2C19
SCHEMBL28417426 0.81 CES2 (0.59) CES2CES1CA1CA2CYP2C19
SCHEMBL22288 0.77 CES2 (0.67) CES2CES1CA1CA2PARP1
SCHEMBL11182680 0.77 TCF4 (0.56) CES2CES1CA1CA2PARP1
SCHEMBL11161016 0.77 TCF4 (0.56) CES2CES1CA1CA2PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6146547-A USEFUL AS COMPONENT OF FERROELECTRIC LIQUID CRYSTAL FORMULATIONS CHISSO CORPORATION (JP) 2000-11-14 US disclosed
EP-0278665-B1 2-Substituted-alkyl ether and liquid crystal composition CHISSO CORP (JP) 1994-09-21 EP disclosed
US-5120468-A Optical active mixture exhibiting ferroelectricity CHISSO CORPORATION (JP) 1992-06-09 US disclosed
EP-0278665-A2 2-Substituted-alkyl ether and liquid crystal composition Chisso Corporation (JP) 1988-08-17 EP disclosed