SCHEMBL22288

SCHEMBL22288

COc1ccc(C(=O)Cl)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.67
CES1 P23141 2/20 0.67
CA1 P00915 6/20 0.64
CA2 P00918 6/20 0.64
PARP10 Q53GL7 2/20 0.61
PARP1 P09874 1/20 0.61
PARP2 Q9UGN5 1/20 0.61
PARP4 Q9UKK3 1/20 0.61
HPGD P15428 2/20 0.61
MAPT P10636 3/20 0.59
LMNA P02545 2/20 0.59
MAPK1 P28482 2/20 0.59
NPSR1 Q6W5P4 2/20 0.59
KDM4E B2RXH2 1/20 0.59
ALDH1A1 P00352 1/20 0.59
ESR1 P03372 1/20 0.59
ADORA3 P0DMS8 1/20 0.59
TSHR P16473 1/20 0.59
CYP2C19 P33261 1/20 0.59
ADRA1A P35348 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27781157 0.98 CES2 (0.64) CES2CES1CA1CA2PARP10
SCHEMBL11511850 0.94 PARP10 (0.66) CES2CES1CA1CA2PARP10
SCHEMBL6667738 0.94 CES2 (0.59) CES2CES1CA1CA2PARP10
SCHEMBL7722030 0.92 HPGD (0.75) CES2CES1CA1CA2PARP10
P-Anisic Acid SCHEMBL11874860 0.92 CA1 (0.80) CES2CES1CA1CA2PARP10
SCHEMBL11763162 0.92 ACHE (0.60) CES2CES1CA1CA2PARP10
SCHEMBL12621087 0.88 LMNA (0.64) CES2CES1CA1CA2PARP10
SCHEMBL15844805 0.88 CES2 (0.53) CES2CES1CA1CA2PARP10
SCHEMBL8733390 0.88 CES2 (0.53) CES2CES1CA1CA2PARP10
SCHEMBL10848800 0.85 CES2 (0.50) CES2CES1CA1CA2PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7348 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122060008-A Indazole alkaloid derivative and preparation method and application thereof 江西师范大学 2026-05-19 CN claimed
CN-122010846-A 1-Phenyl-1H-benzo [ d ] imidazole compound serving as FLT3 kinase inhibitor, preparation method, pharmaceutical composition and application 天津医科大学 2026-05-12 CN claimed
US-12528777-B2 Quinazolinones derivatives for treatment of non-alcoholic fatty liver disease, preparation and use thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2026-01-20 US claimed
EP-3710422-B1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY AND DIASTEREOMERICALLY ENRICHED CYCLOBUTANE AMINES AND AMIDES SYNGENTA CROP PROTECTION AG (CH) 2026-01-07 EP claimed
US-20250282741-A1 NOVEL BENZOFURANYL HYDROXYPHENYL METHANONE DERIVATIVE COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF INNOVO THERAPEUTICS INC. (KR) 2025-09-11 US claimed
CN-119899224-A Triphenylamine derivative, aggregation-induced emission material, and preparation method and application thereof 黄冈师范学院 2025-04-29 CN claimed
CN-119818698-A Micro-molecular drug conjugate based on anisoamide targeted human prostate cancer cells, preparation method and application thereof 华东师范大学 2025-04-15 CN claimed
CN-119569803-A Method for preparing high-purity estetrol 秦皇岛紫竹药业有限公司 2025-03-07 CN claimed
CN-119492837-A Method for detecting N-methyl-D-prolinol isomer 江苏恒瑞医药股份有限公司 2025-02-21 CN claimed
CN-119431424-A Silicon oxime ester-containing photoinitiator, preparation method and application thereof 常州强力先端电子材料有限公司 2025-02-14 CN claimed
EP-0039157-B1 CHLORINATION OF 4-METHOXYBENZOYL CHLORIDE ELI LILLY AND COMPANY (US) 1983-06-15 EP claimed
EP-0005143-B1 1-BENZOYL-2-PYRROLIDINONE DERIVATIVE, PROCESSES FOR ITS PREPARATION AND MEDICAMENTS CONTAINING IT F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1982-07-14 EP claimed
US-4318866-A Chlorination of 4-methoxybenzoyl chloride ELI LILLY AND COMPANY (US) 1982-03-09 US claimed
EP-0039157-A1 Chlorination of 4-methoxybenzoyl chloride ELI LILLY AND COMPANY (US) 1981-11-04 EP claimed
US-4268691-A ANISOYL CHLORIDE, 2,3-DICHLOROANISOLE, LEWIS ACID, APROTIC SOLVENT ABBOTT LABORATORIES (US) 1981-05-19 US claimed
EP-0005143-A1 1-Benzoyl-2-pyrrolidinone derivative, processes for its preparation and medicaments containing it F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1979-11-14 EP claimed
US-4142853-A BENZOYLATION SHIKIBO LIMITED (JP) 1979-03-06 US claimed
US-4113431-A CELLULOSE REACTED WITH A BENZOYLATING AGENT SHIKIBO LIMITED (JP) 1978-09-12 US claimed
US-4093638-A Simultaneous preparation of organic acid chlorides and trichloroacryloyl chloride and product PRODUITS CHIMIQUES PECHINEY-SAINT-GOBAIN (FR) 1978-06-06 US claimed
US-4069252-A Process for the preparation of certain acyl cyanide compounds BAYER AKTIENGESELLSCHAFT (DT) 1978-01-17 US claimed