SCHEMBL8023616

SCHEMBL8023616

Cc1ccc(C(P)(c2ccc(C)cc2)c2ccc3ccccc3c2-c2c(C(P)(c3ccc(C)cc3)c3ccc(C)cc3)ccc3ccccc23)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNJ11 Q14654 1/20 0.40
MAPT P10636 1/20 0.37
RAB9A P51151 3/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
NPC1 O15118 2/20 0.36
CYP2A6 P11509 5/20 0.36
CYP1A2 P05177 3/20 0.36
TSHR P16473 3/20 0.36
HSD17B10 Q99714 3/20 0.36
HPGD P15428 2/20 0.36
HIF1A Q16665 2/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
ALDH1A1 P00352 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
KDM4A O75164 1/20 0.35
CTDSP1 Q9GZU7 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3955070 0.86 HSD17B10 (0.47) MAPTMEN1KMT2ACYP2A6CYP1A2
SCHEMBL6419124 0.85 CYP1A2 (0.38) KCNJ11MAPTRAB9AL3MBTL1NPC1
SCHEMBL5509954 0.83 KCNJ11 (0.44) KCNJ11MAPTRAB9AMEN1KMT2A
SCHEMBL8022205 0.83 KCNJ11 (0.41) KCNJ11MAPTRAB9AMEN1KMT2A
SCHEMBL7776439 0.80 CYP1A2 (0.38) MAPTRAB9AMEN1KMT2AL3MBTL1
SCHEMBL8010370 0.78 CYP2A6 (0.44) KCNJ11MAPTRAB9AMEN1KMT2A
SCHEMBL5828909 0.75 HPGD (0.41) MAPTRAB9AMEN1KMT2AL3MBTL1
SCHEMBL6419265 0.75 P2RX1 (0.41) KCNJ11MAPTMEN1KMT2AL3MBTL1
SCHEMBL6420827 0.75 CYP1A2 (0.37) KCNJ11MAPTMEN1KMT2ACYP2A6
SCHEMBL6418428 0.75 HPRT1 (0.40) KCNJ11MAPTMEN1KMT2ACYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0653432-B1 Process for preparing bis-(diaryl-alkyl)-phosphines and derivatives of this class of substances CELANESE CHEM EUROPE GMBH (DE) 2000-02-09 EP claimed
US-5600006-A Bis(diarylalkyl)phosphines HOECHST A.G. (DE) 1997-02-04 US claimed
EP-0653432-A1 Process for preparing bis-(diaryl-alkyl)-phosphines and novel derivatives of this class of substances HOECHST AKTIENGESELLSCHAFT (DE) 1995-05-17 EP claimed
EP-0653432-B1 Process for preparing bis-(diaryl-alkyl)-phosphines and derivatives of this class of substances CELANESE CHEM EUROPE GMBH (DE) 2000-02-09 EP disclosed
EP-0653432-A1 Process for preparing bis-(diaryl-alkyl)-phosphines and novel derivatives of this class of substances HOECHST AKTIENGESELLSCHAFT (DE) 1995-05-17 EP disclosed