Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | F9 | P00740 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | PRNP | P04156 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8021621 | 0.93 | HPGD (0.48) | HPGDNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8010798 | 0.90 | HPGD (0.53) | HPGDNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10953368 | 0.89 | F9 (0.51) | HPGDNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8024886 | 0.83 | MMP13 (0.48) | HPGDNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL15465845 | 0.79 | EDNRA (0.59) | HPGDNPSR1LMNAGAAKDM4E | |
| SCHEMBL8021176 | 0.78 | KDM4E (0.48) | HPGDNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8412494 | 0.77 | NPSR1 (0.74) | HPGDNPSR1LMNAGAAKDM4E | |
| SCHEMBL8021187 | 0.77 | DYRK1A (0.53) | HPGDNPSR1LMNAGAAKDM4E | |
| SCHEMBL10950755 | 0.76 | CLK1 (0.60) | F9F10LMNADYRK1AGPR132 | |
| SCHEMBL15211326 | 0.76 | SMN1; SMN2 (0.54) | HPGDNPSR1LMNAGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040309-A | ACTIVE MATERIAL TREATING OF RESTENOSIS, RENAL FAILURE, PULMONARY HYPERTENSION, BENIGN PROSTATIC HYPERTROPHY, MALE ERECTILE DYSFUNCTION, CONGESTIVE HEART FAILURE, STROKE, ANGINA, ATHEROSCLEROSIS, CEREBRAL AND CARDIAC ISCHAEMIA | PFIZER, INC. (US) | 2000-03-21 | — | — | US | disclosed |