Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15471999 | 0.87 | MAPT (0.46) | KDM4EHPGDLMNAMAPTL3MBTL1 | |
| SCHEMBL8021621 | 0.79 | HPGD (0.48) | KDM4EHPGDLMNAMAPTL3MBTL1 | |
| SCHEMBL8024350 | 0.78 | HPGD (0.55) | KDM4EHPGDLMNAMAPTL3MBTL1 | |
| SCHEMBL9920686 | 0.77 | MAPT (0.44) | KDM4EHPGDLMNAMAPTL3MBTL1 | |
| SCHEMBL23039633 | 0.71 | HSD17B10 (0.51) | KDM4EHPGDLMNAMAPTL3MBTL1 | |
| SCHEMBL15088051 | 0.71 | ALDH1A1 (0.53) | KDM4EHPGDLMNAKMT2AGAA | |
| SCHEMBL10954630 | 0.71 | CHRNB2 (0.50) | LMNAMAPTKMT2APOLBHTR1A | |
| SCHEMBL8123274 | 0.69 | MAPK1 (0.47) | KDM4EHPGDMAPTKMT2APOLB | |
| SCHEMBL8024886 | 0.69 | MMP13 (0.48) | KDM4EHPGDLMNAMAPTKMT2A | |
| SCHEMBL21874451 | 0.69 | COMT (0.45) | KDM4EHPGDLMNAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040309-A | ACTIVE MATERIAL TREATING OF RESTENOSIS, RENAL FAILURE, PULMONARY HYPERTENSION, BENIGN PROSTATIC HYPERTROPHY, MALE ERECTILE DYSFUNCTION, CONGESTIVE HEART FAILURE, STROKE, ANGINA, ATHEROSCLEROSIS, CEREBRAL AND CARDIAC ISCHAEMIA | PFIZER, INC. (US) | 2000-03-21 | — | — | US | disclosed |