Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | QPCT | Q16769 | 1/20 | 0.34 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024478 | 0.81 | BRD9 (0.42) | MAOAGRM5GRM1CYP1A2METAP2 | |
| SCHEMBL8030192 | 0.81 | SCN9A (0.42) | MTORMAOAKLKB1KDM4EALDH1A1 | |
| SCHEMBL8032003 | 0.79 | PPARD (0.46) | MTORPPARDMAOAQPCTQPCTL | |
| SCHEMBL1011096 | 0.78 | QPCT (0.37) | MTORGABRG2GABRB3GABRA2PPARD | |
| SCHEMBL8034431 | 0.76 | QPCT (0.46) | MTORPPARDMAOAQPCTQPCTL | |
| SCHEMBL8024479 | 0.74 | BRD4 (0.43) | GRM5 | |
| SCHEMBL3811163 | 0.73 | KLKB1 (0.41) | PPARDKLKB1MDM2MEN1KMT2A | |
| SCHEMBL1010607 | 0.73 | GRM5 (0.46) | GRM5ALDH1A1HPGDKMT2A | |
| SCHEMBL1010108 | 0.73 | KLKB1 (0.41) | PPARDGRM5KLKB1MDM2MEN1 | |
| SCHEMBL8028625 | 0.71 | GRM5 (0.38) | MTORMAOAGRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |