Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.42 |
| ▸ | BRD7 | Q9NPI1 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.36 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | HTR1F | P30939 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8030192 | 0.83 | SCN9A (0.42) | MAOA | |
| SCHEMBL8024476 | 0.81 | MTOR (0.36) | MAOAGRM5GRM1CYP1A2METAP2 | |
| SCHEMBL8024479 | 0.79 | BRD4 (0.43) | CD274GRM5 | |
| SCHEMBL8030411 | 0.78 | MAOA (0.46) | BRD9BRD7MAOAGPR84 | |
| SCHEMBL1010583 | 0.77 | CD274 (0.39) | BRD9BRD7MAOACD274PDCD1 | |
| SCHEMBL3817920 | 0.72 | KLKB1 (0.36) | BRD9BRD7CD274PDCD1GRM5 | |
| SCHEMBL8027390 | 0.72 | MAOA (0.53) | MAOACYP1A2 | |
| SCHEMBL1010885 | 0.71 | GRM5 (0.43) | CD274PDCD1GRM5FFAR2 | |
| SCHEMBL1010799 | 0.71 | GRM5 (0.54) | GRM5 | |
| SCHEMBL8024911 | 0.70 | DRD2 (0.49) | MAOAGRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |