Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.42 |
| ▸ | OXTR | P30559 | 2/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8026577 | 0.83 | GRM5 (0.41) | GRM5DRD2DRD1DRD4DRD5 | |
| SCHEMBL8024478 | 0.79 | BRD9 (0.42) | GRM5CD274 | |
| SCHEMBL8025384 | 0.78 | ADRA2A (0.48) | GRM5DRD2DRD1DRD4DRD5 | |
| SCHEMBL8022093 | 0.77 | DRD2 (0.37) | GRM5DRD2DRD1DRD4DRD5 | |
| SCHEMBL1010376 | 0.77 | BRD4 (0.46) | BRD4CREBBPJAK2GRM5HSD17B1 | |
| SCHEMBL8024959 | 0.76 | DRD1 (0.46) | BRD4GRM5DRD1 | |
| SCHEMBL8024911 | 0.76 | DRD2 (0.49) | GRM5DRD2DRD1DRD4DRD5 | |
| SCHEMBL8030192 | 0.76 | SCN9A (0.42) | CHRNB4CHRNA3 | |
| SCHEMBL8032011 | 0.76 | MAOA (0.49) | HSD17B1HSD17B2CYP2A6CD274 | |
| SCHEMBL8024476 | 0.74 | MTOR (0.36) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |