Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Sulfacarbamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | DHFR | P00374 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 2/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.49 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfacarbamide SCHEMBL154846 | 0.87 | TSHR (0.69) | KMT2AMEN1LMNASMN1; SMN2TDP1 | |
| Sulfabenzamide SCHEMBL93841 | 0.82 | KMT2A (1.00) | KMT2AMEN1LMNASMN1; SMN2TDP1 | |
| SCHEMBL370189 | 0.81 | CA2 (0.56) | KMT2AMEN1LMNASMN1; SMN2CA1 | |
| Sulfabenzamide SCHEMBL16415986 | 0.81 | KMT2A (0.97) | KMT2AMEN1LMNASMN1; SMN2TDP1 | |
| SCHEMBL5605338 | 0.79 | CA2 (0.54) | KMT2AMEN1LMNASMN1; SMN2CA1 | |
| Benzoic Acid SCHEMBL28791533 | 0.79 | LMNA (0.62) | KMT2AMEN1LMNASMN1; SMN2TDP1 | |
| Sulfacarbamide SCHEMBL3499035 | 0.79 | TSHR (0.64) | KMT2AMEN1LMNASMN1; SMN2TDP1 | |
| Sulfanilamide SCHEMBL28647643 | 0.78 | CA1 (0.71) | KMT2AMEN1LMNATDP1TSHR | |
| SCHEMBL29176138 | 0.78 | HTR6 (0.52) | KMT2AMEN1LMNAPRMT1FLT1 | |
| Benzoic Acid SCHEMBL27308628 | 0.77 | TSHR (0.74) | KMT2AMEN1LMNATDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539530-B1 | PURIFICATION DIRECTED CLONING OF PEPTIDES | BIONEBRASKA INC (US) | 2000-02-02 | — | — | EP | disclosed |