Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.32 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.31 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010859 | 0.72 | MAOA (0.33) | HTR2AHTR2CHTR2BMAOAMEN1 | |
| SCHEMBL25338505 | 0.66 | MAOA (0.66) | MAOAMEN1KMT2ASIRT6ALDH1A1 | |
| SCHEMBL27156382 | 0.66 | MAOA (0.66) | MAOAMEN1KMT2ASIRT6ALDH1A1 | |
| SCHEMBL15770536 | 0.64 | MAPT (0.42) | MEN1KMT2ASIRT6MAPTALDH1A1 | |
| SCHEMBL8015301 | 0.64 | HTR1A (0.52) | HTR2AMAOASIRT6 | |
| SCHEMBL8031034 | 0.64 | HTR1A (0.55) | HTR2AMAOAMEN1KMT2ASIRT6 | |
| Hydrochloric Acid SCHEMBL7509854 | 0.63 | HTR1A (0.51) | HTR2AMAOASIRT6 | |
| SCHEMBL16857343 | 0.63 | TDP1 (0.37) | MEN1KMT2AALDH1A1 | |
| SCHEMBL1473281 | 0.60 | TDP1 (0.56) | MEN1KMT2AALDH1A1 | |
| SCHEMBL31319374 | 0.60 | CDK2 (0.40) | MEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |