Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | DRD1 | P21728 | 3/20 | 0.55 |
| ▸ | MAOA | P21397 | 3/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | PNMT | P11086 | 3/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8015301 | 0.88 | HTR1A (0.52) | HTR1ADRD1MAOAHIF1ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7509854 | 0.87 | HTR1A (0.51) | HTR1ADRD1MAOAHIF1ASMN1; SMN2 | |
| SCHEMBL28294149 | 0.85 | DRD1 (0.55) | HTR1ADRD1HIF1ASMN1; SMN2HTT | |
| SCHEMBL2272695 | 0.80 | HTR1A (0.47) | HTR1ADRD1HIF1ASMN1; SMN2HTT | |
| SCHEMBL1950525 | 0.74 | PNMT (0.54) | HTR1ADRD1HIF1ASMN1; SMN2HTT | |
| SCHEMBL4752284 | 0.73 | MAOA (0.56) | HTR1ADRD1MAOAADRA2CDRD2 | |
| SCHEMBL3950020 | 0.73 | MAOA (0.56) | HTR1ADRD1MAOAADRA2CDRD2 | |
| SCHEMBL8032013 | 0.73 | MAOA (0.56) | HTR1AMAOADRD2HTR2A | |
| SCHEMBL8011243 | 0.73 | MAOA (0.56) | HTR1AMAOAPNMTADRA2AADRA2B | |
| SCHEMBL25338505 | 0.72 | MAOA (0.66) | MAOASMN1; SMN2HTTNCOA1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |