Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KCNN2 | Q9H2S1 | 4/20 | 0.32 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.32 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8028587 | 0.90 | MAOA (0.45) | MAOAKDM4EALDH1A1HSD17B10PLAU | |
| SCHEMBL8024459 | 0.78 | MAOA (0.47) | MAOAKDM4EALDH1A1MAPK1DRD2 | |
| SCHEMBL8024842 | 0.77 | MAOA (0.43) | MAOADRD2DRD1DRD4 | |
| SCHEMBL8014184 | 0.76 | DRD2 (0.46) | MAOADRD2 | |
| SCHEMBL8028066 | 0.75 | CHEK1 (0.46) | MAOALMNAALDH1A1HSD17B10 | |
| SCHEMBL8028105 | 0.75 | MAOA (0.49) | MAOADRD2DRD1DRD4 | |
| SCHEMBL8027330 | 0.74 | MAOA (0.48) | MAOADRD2 | |
| SCHEMBL8023498 | 0.71 | CYP11B1 (0.51) | — | |
| SCHEMBL8014211 | 0.71 | MAOA (0.44) | MAOA | |
| SCHEMBL8023049 | 0.70 | MAOA (0.47) | MAOAKDM4EALDH1A1HSD17B10CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |