Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | BCR | P11274 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024831 | 0.90 | DRD2 (0.48) | DRD2MAOAHTR1AHTR7GSK3B | |
| SCHEMBL8028189 | 0.79 | GRIA2 (0.43) | MAOADYRK1APRMT5WDR77 | |
| SCHEMBL8024459 | 0.78 | MAOA (0.47) | DRD2MAOADYRK1A | |
| SCHEMBL8028105 | 0.78 | MAOA (0.49) | DRD2MAOA | |
| SCHEMBL12891743 | 0.78 | DRD2 (0.41) | DRD2HTR1AHTR7GSK3BDYRK1A | |
| SCHEMBL26820010 | 0.78 | DRD2 (0.41) | DRD2HTR1AHTR7GSK3BDYRK1A | |
| SCHEMBL12891748 | 0.78 | DRD2 (0.41) | DRD2HTR1AHTR7GSK3BDYRK1A | |
| SCHEMBL8014207 | 0.77 | MAOA (0.46) | MAOAGSK3B | |
| SCHEMBL8023498 | 0.76 | CYP11B1 (0.51) | — | |
| SCHEMBL8024955 | 0.76 | MAOA (0.45) | DRD2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |