Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | EPOR | P19235 | 5/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | SLC1A5 | Q15758 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8025565 | 1.00 | DPP8 (0.43) | DPP8GSREPORLTA4HDPP7 | |
| Lysine SCHEMBL8035746 | 0.94 | DPP8 (0.41) | DPP8GSREPORLTA4HDPP7 | |
| Lysine SCHEMBL8035745 | 0.94 | DPP8 (0.41) | DPP8GSREPORLTA4HDPP7 | |
| Lysine SCHEMBL8035235 | 0.92 | DPP8 (0.45) | DPP8GSRLTA4HDPP7 | |
| Lysine SCHEMBL8035239 | 0.92 | DPP8 (0.45) | DPP8GSRLTA4HDPP7 | |
| Lysine SCHEMBL8037512 | 0.91 | KMO (0.38) | DPP8GSRCTSLCTSBCTSS | |
| Lysine SCHEMBL8037515 | 0.91 | KMO (0.38) | DPP8GSRCTSLCTSBCTSS | |
| Cyclohexylamine SCHEMBL8037294 | 0.89 | EPOR (0.41) | EPORLTA4HPKMHPGD | |
| Cyclohexylamine SCHEMBL8037292 | 0.89 | EPOR (0.41) | EPORLTA4HPKMHPGD | |
| Lysine SCHEMBL8039122 | 0.89 | GSR (0.48) | DPP8GSRDPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |