Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 7/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.48 |
| ▸ | GRM6 | O15303 | 2/20 | 0.48 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8041461 | 0.86 | KDM4E (0.40) | GFEREGFRMAPTSMN1; SMN2KDM4E | |
| Cyclohexylamine SCHEMBL7798783 | 0.86 | POLB (0.49) | POLBGFEREGFRJUNTDP1 | |
| Cyclohexylamine SCHEMBL7798524 | 0.84 | POLB (0.56) | POLBGFEREGFRJUNTDP1 | |
| Lysine SCHEMBL8037517 | 0.82 | GRM4 (0.43) | GRM8GRM4GRM6GRM7 | |
| Lysine SCHEMBL8037518 | 0.82 | GRM4 (0.43) | GRM8GRM4GRM6GRM7 | |
| Isovanillin SCHEMBL8041270 | 0.81 | ALDH1A1 (0.48) | POLBTDP1MAPTSMN1; SMN2KDM4E | |
| Isovanillin SCHEMBL8041267 | 0.81 | ALDH1A1 (0.48) | POLBTDP1MAPTSMN1; SMN2KDM4E | |
| Lysine SCHEMBL8041446 | 0.80 | GSR (0.43) | — | |
| Lysine SCHEMBL8041442 | 0.80 | GSR (0.43) | — | |
| Lysine SCHEMBL8041480 | 0.79 | GSR (0.39) | TDP1SMN1; SMN2KDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |