Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 9/20 | 0.43 |
| ▸ | GRM8 | O00222 | 8/20 | 0.43 |
| ▸ | GRM6 | O15303 | 7/20 | 0.39 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.39 |
| ▸ | ABAT | P80404 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | GRM7 | Q14831 | 5/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8037517 | 1.00 | GRM4 (0.43) | GRM4GRM8GRM6ALDH5A1ABAT | |
| Cyclohexylamine SCHEMBL8025542 | 0.89 | ALDH5A1 (0.42) | GRM4GRM8GRM6ALDH5A1ABAT | |
| Cyclohexylamine SCHEMBL8025550 | 0.89 | ALDH5A1 (0.42) | GRM4GRM8GRM6ALDH5A1ABAT | |
| Lysine SCHEMBL7803083 | 0.86 | MMP2 (0.43) | GRM4GRM8GRM6GSR | |
| Lysine SCHEMBL7803085 | 0.86 | MMP2 (0.43) | GRM4GRM8GRM6GSR | |
| Cyclohexylamine SCHEMBL7798582 | 0.85 | ALDH5A1 (0.46) | GRM4GRM8ALDH5A1ABATXDH | |
| 3-Nitrobenzaldehyde SCHEMBL8035795 | 0.84 | KMO (0.43) | GRM4GRM8GRM6GSR | |
| 3-Nitrobenzaldehyde SCHEMBL8035793 | 0.84 | KMO (0.43) | GRM4GRM8GRM6GSR | |
| Cyclohexylamine SCHEMBL7801795 | 0.84 | ALDH5A1 (0.54) | ALDH5A1ABATXDH | |
| Lysine SCHEMBL8039332 | 0.83 | MMP2 (0.41) | GRM4GRM8GRM6GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |