Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.42 |
| ▸ | DRD3 | P35462 | 9/20 | 0.42 |
| ▸ | DRD4 | P21917 | 7/20 | 0.42 |
| ▸ | DRD1 | P21728 | 5/20 | 0.42 |
| ▸ | DRD5 | P21918 | 5/20 | 0.42 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8015186 | 0.76 | RHEB (0.47) | RHEBMTNR1B | |
| SCHEMBL13604212 | 0.73 | DRD2 (0.46) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL30707207 | 0.72 | CCR4 (0.40) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL29706003 | 0.72 | MEN1 (0.42) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL203899 | 0.72 | MEN1 (0.42) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL8015473 | 0.70 | MAPT (0.42) | RHEB | |
| SCHEMBL3927466 | 0.69 | DRD2 (0.34) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL4376769 | 0.69 | DRD2 (0.46) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL13678676 | 0.69 | KDM4E (0.43) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL12476299 | 0.68 | MEN1 (0.41) | DRD2DRD3DRD4DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000061554-A1 | 1-AMINO ETHYLINDOLE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | SANOFI-SYNTHELABO (FR) | 2000-10-19 | — | — | WO | disclosed |
| WO-2000061553-A1 | 2-AMINOETHYL-INDOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | SANOFI-SYNTHELABO (FR) | 2000-10-19 | — | — | WO | disclosed |