Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL270835 | 0.74 | CYP19A1 (0.40) | TSHRNPSR1HSD17B10CYP19A1CYP2D6 | |
| SCHEMBL4880953 | 0.74 | CYP19A1 (0.56) | TSHRMAPK1NPSR1ADRA2AHIF1A | |
| SCHEMBL11293329 | 0.73 | KDM4E (0.52) | TSHRLMNANPSR1HSD17B10KDM4E | |
| SCHEMBL12770874 | 0.70 | CYP2D6 (0.54) | LMNANPSR1HSD17B10KDM4ECYP2D6 | |
| SCHEMBL12770872 | 0.70 | CYP2D6 (0.54) | LMNANPSR1HSD17B10KDM4ECYP2D6 | |
| SCHEMBL7009772 | 0.70 | CYP2D6 (0.54) | LMNANPSR1HSD17B10KDM4ECYP2D6 | |
| SCHEMBL946807 | 0.70 | TSHR (0.48) | TSHRLMNANPSR1HSD17B10CYP19A1 | |
| SCHEMBL10841420 | 0.70 | LMNA (0.53) | TSHRLMNAMAPK1NPSR1HSD17B10 | |
| SCHEMBL10812702 | 0.69 | ESR1 (0.43) | TSHRCYP2D6 | |
| SCHEMBL812049 | 0.68 | LMNA (0.44) | TSHRLMNAMAPK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |
| WO-2000051610-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-09-08 | — | — | WO | disclosed |