Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 12/20 | 0.77 |
| ▸ | ACE | P12821 | 9/20 | 0.77 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8017233 | 0.95 | MME (0.68) | MMEACEPSEN1PSEN2APH1B | |
| SCHEMBL8017187 | 0.93 | MME (0.78) | MMEACEPSEN1PSEN2APH1B | |
| SCHEMBL8027132 | 0.93 | MME (0.68) | MMEACEPSEN1PSEN2APH1B | |
| SCHEMBL27464921 | 0.92 | MME (0.65) | MMEACEPSEN1PSEN2APH1B | |
| SCHEMBL8032886 | 0.90 | MME (0.62) | MMEACEPSEN1PSEN2APH1B | |
| SCHEMBL8027155 | 0.89 | MME (0.79) | MMEACEPSEN1PSEN2APH1B | |
| SCHEMBL8026891 | 0.88 | MME (0.80) | MMEACEACE2 | |
| SCHEMBL8026896 | 0.88 | MME (0.80) | MMEACEACE2 | |
| SCHEMBL8448663 | 0.88 | MME (0.80) | MMEACEACE2 | |
| SCHEMBL8030182 | 0.88 | MME (0.69) | MMEACEPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738711-B1 | NOVEL 1,3-DIALKYLUREA DERIVATIVE HAVING HYDROXYL GROUP | SANTEN PHARMACEUTICAL CO LTD (JP) | 2000-03-08 | — | — | EP | disclosed |
| EP-0738711-A1 | NOVEL 1,3-DIALKYLUREA DERIVATIVE HAVING HYDROXYL GROUP | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1996-10-23 | — | — | EP | disclosed |