SCHEMBL8027426

SCHEMBL8027426

O=C(CCl)Nc1cc(Cl)c(O)c2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EP300 Q09472 1/20 0.47
BRAF P15056 1/20 0.46
MCL1 Q07820 2/20 0.45
ALDH1A1 P00352 11/20 0.44
HTT P42858 5/20 0.44
LMNA P02545 4/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
MAPT P10636 3/20 0.44
HSD11B1 P28845 1/20 0.44
BLM P54132 2/20 0.43
NPSR1 Q6W5P4 2/20 0.43
NOD2 Q9HC29 1/20 0.43
MEN1 O00255 5/20 0.43
KMT2A Q03164 5/20 0.43
KDM4E B2RXH2 4/20 0.42
PKM P14618 2/20 0.41
NPC1 O15118 2/20 0.41
MITF O75030 2/20 0.41
RAB9A P51151 2/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8030052 0.86 GABRP (0.49) EP300BRAFMCL1ALDH1A1HTT
SCHEMBL4866643 0.79 ALDH1A1 (0.51) EP300ALDH1A1HTTLMNASMN1; SMN2
SCHEMBL2680971 0.76 EP300 (0.60) EP300ALDH1A1HTTLMNASMN1; SMN2
SCHEMBL1272337 0.74 KMT2A (0.70) ALDH1A1HTTLMNABLMNPSR1
SCHEMBL31170708 0.73 MEN1 (0.56) ALDH1A1HTTLMNASMN1; SMN2MAPT
SCHEMBL4011016 0.73 ALDH1A1 (0.65) ALDH1A1HTTLMNASMN1; SMN2MAPT
SCHEMBL7026999 0.73 ALDH1A1 (0.49) ALDH1A1HTTLMNASMN1; SMN2MAPT
SCHEMBL13510394 0.73 EP300 (0.62) EP300BRAFMCL1ALDH1A1HTT
SCHEMBL8028208 0.72 ALDH1A1 (0.59) EP300ALDH1A1HTTLMNASMN1; SMN2
SCHEMBL7291409 0.72 ALDH1A1 (0.54) ALDH1A1HTTLMNASMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0603954-B1 Immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer JOHNSON & JOHNSON CLIN DIAG (US) 2000-03-08 EP disclosed
EP-0603953-B1 Use of 4' of 5'-hydroxy and 4'- or 5'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods JOHNSON & JOHNSON CLIN DIAG (US) 1999-02-17 EP disclosed
US-5736335-A Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents EASTMAN KODAK COMPANY (US) 1998-04-07 US disclosed
US-5641635-A Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents EASTMAN KODAK COMPANY (US) 1997-06-24 US disclosed
US-5372931-A Use of 4'-hydroxy- and 4'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods EASTMAN KODAK COMPANY (US) 1994-12-13 US disclosed
US-5372932-A Peroxidase-labeled immunoreactant; stabiliztion with a 4-hydroxy or 4-alkoxyarylacetamide EASTMAN KODAK COMPANY (US) 1994-12-13 US disclosed
EP-0603953-A1 Use of 4' of 5'-hydroxy and 4'- or 5'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-06-29 EP disclosed
EP-0603954-A2 Analytical element and immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-06-29 EP disclosed