SCHEMBL8027780

SCHEMBL8027780

Cc1ccc(NC(=O)C(Oc2ccc(OC3CCCCCCC3)cc2)c2ccccc2)c(C(=O)O)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCC1 P33527 1/20 0.47
ALDH1A1 P00352 2/20 0.43
MEN1 O00255 5/20 0.42
KMT2A Q03164 5/20 0.42
KDM4E B2RXH2 2/20 0.42
HSD17B10 Q99714 1/20 0.42
GFER P55789 2/20 0.41
IDO1 P14902 1/20 0.40
HPGD P15428 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ADRB1 P08588 1/20 0.39
ADRB3 P13945 1/20 0.39
TSHR P16473 2/20 0.39
SRD5A1 P18405 1/20 0.39
PPARG P37231 1/20 0.38
PPARA Q07869 1/20 0.38
HTR1E P28566 1/20 0.38
S1PR3 Q99500 1/20 0.38
MAOB P27338 1/20 0.38
METAP2 P50579 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8037972 0.92 ALDH1A1 (0.44) ABCC1ALDH1A1MEN1KMT2AKDM4E
SCHEMBL8041280 0.88 SERPINE1 (0.46) ALDH1A1KMT2AKDM4EHSD17B10L3MBTL1
SCHEMBL8039706 0.88 ABCC1 (0.45) ABCC1ALDH1A1MEN1KMT2AKDM4E
SCHEMBL8039543 0.88 ABCC1 (0.45) ABCC1ALDH1A1MEN1KMT2AKDM4E
SCHEMBL8039714 0.88 ABCC1 (0.45) ABCC1ALDH1A1MEN1KMT2AKDM4E
SCHEMBL8038300 0.88 ABCC1 (0.45) ABCC1ALDH1A1MEN1KMT2AKDM4E
SCHEMBL8039687 0.87 SRD5A1 (0.43) ABCC1ALDH1A1MEN1KMT2AKDM4E
SCHEMBL8037924 0.83 TSHR (0.54) ALDH1A1KMT2AKDM4EHSD17B10HPGD
SCHEMBL8041066 0.83 TSHR (0.54) ALDH1A1KMT2AKDM4EHSD17B10HPGD
SCHEMBL8037888 0.82 TSHR (0.55) ALDH1A1KMT2AKDM4EHSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0806412-B1 BENZENE DERIVATIVES TEIJIN LTD (JP) 2000-04-05 EP disclosed