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SCHEMBL8028040

SCHEMBL8028040

COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(N)nc3=O)C[C@@H]2O[PH](O)(CC=CC[SiH2]C(c2ccccc2)c2ccccc2)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ TYMP P19971 2/20 0.35
▸ POLB P06746 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8034055 0.85 RNASE1 (0.40) TYMP
SCHEMBL8033756 0.84 TYMP (0.41) TYMPPOLB
SCHEMBL15301519 0.84 TYMP (0.36) TYMPPOLB
SCHEMBL7037018 0.80 POLB (0.47) TYMPPOLB
SCHEMBL6885492 0.76 POLB (0.53) TYMPPOLB
SCHEMBL6885494 0.76 POLB (0.53) TYMPPOLB
SCHEMBL20527120 0.75 TYMP (0.41) TYMPPOLB
SCHEMBL20527126 0.75 TYMP (0.39) TYMPPOLB
SCHEMBL6232615 0.75 RNASE1 (0.42) TYMP
SCHEMBL13036643 0.74 TYMP (0.42) TYMPPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6051699-A Process for the synthesis of oligomeric compounds ISIS PHARMACEUTICALS, INC. (US) 2000-04-18 — — US disclosed
US-5859232-A Process for the synthesis of oligomeric phosphite, phosphodiester, phosphorothioate and phosphorodithioate compounds ISIS PHARMACEUTICALS, INC. (US) 1999-01-12 — — US disclosed
US-5705621-A Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same ISIS PHARMACEUTICALS, INC. (US) 1998-01-06 — — US disclosed