Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8028186 | 0.89 | KDM4E (0.36) | ALDH1A1BRD4CREBBPPOLBGAA | |
| SCHEMBL8024749 | 0.80 | ALDH1A1 (0.46) | ALDH1A1BRD4CREBBPPOLBGAA | |
| SCHEMBL21585948 | 0.78 | MAOB (0.57) | ALDH1A1GAAMEN1KMT2AMAPT | |
| SCHEMBL21586009 | 0.70 | PTPN1 (0.37) | ALDH1A1KMT2AHTR2CKDM4E | |
| SCHEMBL8024372 | 0.69 | MAOB (0.50) | ALDH1A1GAAMEN1KMT2AMAPT | |
| SCHEMBL22476283 | 0.69 | KMT2A (0.43) | POLBMEN1KMT2AMAPTHTR2C | |
| SCHEMBL8024775 | 0.69 | SLC6A2 (0.49) | ALDH1A1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL7745894 | 0.66 | MEN1 (0.51) | ALDH1A1BRD4CREBBPPOLBGAA | |
| SCHEMBL13323 | 0.66 | ALDH1A1 (0.60) | ALDH1A1BRD4CREBBPPOLBGAA | |
| SCHEMBL9817710 | 0.65 | ALDH1A1 (0.47) | ALDH1A1BRD4CREBBPPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0792268-B1 | HYPOLIPIDEMIC BENZOTHIAZEPINES | WELLCOME FOUND (GB) | 2000-02-23 | — | — | EP | disclosed |
| US-5998400-A | Hypolipidemic benzothiazepines | GLAXO WELLCOME INC. (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0792268-A1 | HYPOLIPIDEMIC BENZOTHIAZEPINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996016051-A1 | HYPOLIPIDEMIC BENZOTHIAZEPINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-05-30 | — | — | WO | disclosed |