Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 3/20 | 0.33 |
| ▸ | MMP9 | P14780 | 3/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8028203 | 0.89 | ALDH1A1 (0.41) | KDM4EHPGDALDH1A1BRD4CREBBP | |
| SCHEMBL8024372 | 0.81 | MAOB (0.50) | KDM4EHPGDALDH1A1MMP2MMP9 | |
| SCHEMBL27453871 | 0.77 | SIGMAR1 (0.33) | ELANE | |
| SCHEMBL6843532 | 0.76 | GHSR (0.36) | ALDH1A1MMP13HTR7MEN1MAPT | |
| SCHEMBL5227372 | 0.75 | MAOB (0.52) | KDM4EHPGDALDH1A1MMP2MMP9 | |
| SCHEMBL8031445 | 0.74 | PTPN1 (0.38) | KDM4EALDH1A1KMT2A | |
| SCHEMBL21585955 | 0.74 | LMNA (0.34) | ALDH1A1MAPTKMT2ANPSR1 | |
| SCHEMBL21586026 | 0.74 | SLC10A2 (0.31) | KMT2A | |
| SCHEMBL8024749 | 0.73 | ALDH1A1 (0.46) | KDM4EHPGDALDH1A1BRD4CREBBP | |
| SCHEMBL6310246 | 0.71 | SLC10A2 (0.38) | ELANEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0792268-B1 | HYPOLIPIDEMIC BENZOTHIAZEPINES | WELLCOME FOUND (GB) | 2000-02-23 | — | — | EP | disclosed |
| US-5998400-A | Hypolipidemic benzothiazepines | GLAXO WELLCOME INC. (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0792268-A1 | HYPOLIPIDEMIC BENZOTHIAZEPINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996016051-A1 | HYPOLIPIDEMIC BENZOTHIAZEPINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-05-30 | — | — | WO | disclosed |