Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024647 | 0.81 | PDE4B (0.46) | PDE4BPDE4D | |
| SCHEMBL15906152 | 0.80 | HSD17B10 (0.50) | SYKAURKBINCENPADORA1L3MBTL1 | |
| SCHEMBL3787844 | 0.78 | PDE4B (0.59) | PDE4BPDE4DCTSAMAPTTP53 | |
| SCHEMBL8053232 | 0.77 | PDE4B (0.45) | PDE4BPDE4D | |
| SCHEMBL11996295 | 0.77 | SYK (0.40) | PDE4BSYKAURKBINCENPADORA1 | |
| SCHEMBL8071898 | 0.76 | PDE4B (0.56) | PDE4BPDE4D | |
| SCHEMBL3785840 | 0.74 | PDE4B (0.59) | PDE4BADORA1CTSAMAPT | |
| SCHEMBL8031101 | 0.74 | HDAC4 (0.46) | PDE4BCTSAMAPTTP53 | |
| SCHEMBL8066265 | 0.73 | HTR1A (0.46) | CTSAMAPTTP53 | |
| SCHEMBL8071504 | 0.73 | CXCR4 (0.46) | PDE4BMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |
| WO-2009067621-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |