Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070648 | 0.80 | PDE4B (0.42) | PDE4BALDH1A1SMN1; SMN2NPC1LMNA | |
| SCHEMBL3794467 | 0.80 | PDE4B (0.60) | CXCR4PDE4BSMN1; SMN2MAPTNPC1 | |
| SCHEMBL8066164 | 0.79 | PDE4B (0.44) | PDE4BMAPT | |
| SCHEMBL8024647 | 0.79 | PDE4B (0.46) | PDE4B | |
| SCHEMBL8053232 | 0.75 | PDE4B (0.45) | PDE4B | |
| SCHEMBL8028328 | 0.73 | PDE4B (0.41) | PDE4BMAPTTP53 | |
| SCHEMBL8071898 | 0.73 | PDE4B (0.56) | PDE4B | |
| SCHEMBL8072345 | 0.73 | PDE4B (0.46) | PDE4BALDH1A1MAPT | |
| SCHEMBL29604383 | 0.66 | CXCR4 (1.00) | CXCR4ALDH1A1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL22167005 | 0.66 | CXCR4 (0.61) | CXCR4ALDH1A1SMN1; SMN2NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |