Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | KCNN2 | Q9H2S1 | 4/20 | 0.41 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.41 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019032 | 0.88 | SLC6A4 (0.46) | SLC6A4DRD2DRD4KCNN2KCNN3 | |
| SCHEMBL8012740 | 0.79 | MAOA (0.56) | SLC6A4HTR2AHTR2CMAOA | |
| SCHEMBL8029002 | 0.79 | MAOA (0.56) | SLC6A4HTR2AHTR2CMAOA | |
| SCHEMBL23057928 | 0.77 | PRCP (0.56) | SLC6A4DRD2DRD1OPRK1SLC6A3 | |
| SCHEMBL21890121 | 0.77 | PRCP (0.56) | SLC6A4DRD2DRD1OPRK1SLC6A3 | |
| SCHEMBL8024199 | 0.77 | PRCP (0.56) | SLC6A4DRD2DRD1OPRK1SLC6A3 | |
| SCHEMBL8032022 | 0.76 | HTR2A (0.43) | SLC6A4HTR2AHTR2CDRD2MAOA | |
| SCHEMBL12633796 | 0.74 | DRD2 (0.65) | DRD2DRD4KCNN2KCNN3KCNN1 | |
| SCHEMBL13878183 | 0.72 | KCNN2 (0.76) | KCNN2KCNN3KCNN1LMNAKDM4E | |
| SCHEMBL5249611 | 0.71 | DRD2 (0.49) | SLC6A4DRD2KDM4EDRD1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |