Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8030423 | 0.87 | SRD5A1 (0.43) | SLC6A4MAOANOTUMDRD2 | |
| SCHEMBL8029002 | 0.80 | MAOA (0.56) | HTR2AHTR2CSLC6A4MAOAPLAU | |
| SCHEMBL8012740 | 0.80 | MAOA (0.56) | HTR2AHTR2CSLC6A4MAOAPLAU | |
| SCHEMBL8025796 | 0.78 | PRCP (0.56) | MAOAPRCPDRD2 | |
| SCHEMBL8028632 | 0.76 | SLC6A4 (0.46) | HTR2AHTR2CSLC6A4MAOADRD2 | |
| SCHEMBL5249611 | 0.72 | DRD2 (0.49) | SLC6A4PRCPDRD2 | |
| SCHEMBL8032013 | 0.70 | MAOA (0.56) | HTR2AHTR2CSLC6A4MAOANOTUM | |
| SCHEMBL5245716 | 0.70 | KDM4E (0.51) | PRCPDRD2 | |
| SCHEMBL27156762 | 0.69 | MAOA (0.50) | MAOA | |
| SCHEMBL8030400 | 0.68 | MEN1 (0.42) | HTR2AHTR2CPRCPNOTUMDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |