Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Deoxyadenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DTYMK | P23919 | 4/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
| ▸ | TK1 | P04183 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | PNP | P00491 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxribtimine SCHEMBL8366525 | 0.92 | TK1 (0.53) | LMNATSHRALBTK1PKM | |
| Doxribtimine SCHEMBL1164058 | 0.92 | TK1 (0.53) | LMNATSHRALBTK1PKM | |
| Deoxyadenosine SCHEMBL20819422 | 0.92 | DTYMK (0.67) | DTYMKHIF1AFPR2DNMT1DNMT3B | |
| Doxribtimine SCHEMBL9465657 | 0.91 | TK1 (0.51) | LMNATSHRALBTK1PKM | |
| Doxribtimine SCHEMBL5964873 | 0.89 | TK1 (0.50) | LMNATSHRALBTK1PKM | |
| Deoxyinosine SCHEMBL8026167 | 0.88 | DTYMK (0.49) | DTYMKHIF1ALMNATSHRALB | |
| Doxribtimine SCHEMBL28237206 | 0.88 | LMNA (0.51) | DTYMKLMNATSHRALBTK1 | |
| Doxribtimine SCHEMBL10409131 | 0.87 | LMNA (0.47) | DTYMKLMNATSHRALBTK1 | |
| Deoxyadenosine SCHEMBL10012867 | 0.86 | DTYMK (0.61) | DTYMKHIF1AFPR2DNMT1DNMT3B | |
| Doxribtimine SCHEMBL27149426 | 0.85 | TK1 (0.46) | LMNATSHRALBTK1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017736-A | HIGH YIELD PROCESS BY BASE EXCHANGE REACTION BETWEEN PYRIMIDINE NUCLEOSIDE AND PURINE BASE IN PHOSPHATE ION-CONTAINING AQUEOUS SOLUTION IN PRESENCE OF PURINE AND PYRIMIDINE NUCLEOSIDE PHOSPHORYLASES | YUKI GOSEI KOGYO CO., LTD. (JP) | 2000-01-25 | — | — | US | disclosed |