Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 7/20 | 0.35 |
| ▸ | DRD1 | P21728 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 6/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD5 | P21918 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3308482 | 0.85 | DRD2 (0.35) | ACEDRD2DRD1DRD3DRD4 | |
| SCHEMBL15222058 | 0.69 | MAOA (0.43) | — | |
| SCHEMBL8030397 | 0.69 | MAOA (0.43) | — | |
| SCHEMBL8324725 | 0.69 | MAOA (0.43) | — | |
| SCHEMBL11923826 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL8089203 | 0.67 | NPSR1 (0.42) | DRD1DRD3DRD4CYP2C19 | |
| Hydrochloric Acid SCHEMBL8092726 | 0.66 | KDM4E (0.56) | DRD2DRD1DRD3DRD4CYP2C19 | |
| SCHEMBL12363794 | 0.65 | DRD2 (0.35) | ACEDRD2DRD1DRD3DRD4 | |
| SCHEMBL8024910 | 0.64 | CHRM2 (0.34) | — | |
| SCHEMBL788875 | 0.64 | DRD1 (0.66) | DRD2DRD1DRD3DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |