Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.85 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitecapone SCHEMBL128420 | 0.92 | GPR35 (1.00) | GPR35GLO1ALDH1A1MEN1MAPT | |
| Nitecapone SCHEMBL7039409 | 0.92 | GPR35 (1.00) | GPR35GLO1ALDH1A1MEN1MAPT | |
| Nitecapone SCHEMBL30489171 | 0.92 | GPR35 (1.00) | GPR35GLO1ALDH1A1MEN1MAPT | |
| SCHEMBL7279215 | 0.87 | GPR35 (0.70) | GPR35ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL16884524 | 0.83 | GPR35 (0.65) | GPR35GLO1ALDH1A1MEN1MAPT | |
| SCHEMBL9252649 | 0.81 | GPR35 (0.62) | GPR35GLO1ALDH1A1MEN1MAPT | |
| SCHEMBL7287709 | 0.81 | GPR35 (0.70) | GPR35GLO1ALDH1A1MEN1MAPT | |
| SCHEMBL7279195 | 0.79 | GPR35 (0.78) | GPR35ALDH1A1MEN1MAPTHPGD | |
| SCHEMBL7279188 | 0.79 | GPR35 (0.78) | GPR35ALDH1A1MEN1MAPTHPGD | |
| SCHEMBL8045644 | 0.79 | GLO1 (0.71) | GPR35GLO1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0440324-B1 | Substituted beta-diketones and their use in the treatment of inflammatory bowel disease | ORION YHTYMAE OY (FI) | 2000-04-12 | — | — | EP | disclosed |
| US-5292771-A | Treating inflammatory bowel disease | ORION-YHTYMA OY (FI) | 1994-03-08 | — | — | US | disclosed |
| US-5185370-A | Substituted β-diketones and their use | ORION-YHTYMA OY (FI) | 1993-02-09 | — | — | US | disclosed |
| EP-0440324-A2 | Substituted beta-diketones and their use | ORION-YHTYMÀ OY (FI) | 1991-08-07 | — | — | EP | disclosed |