Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23002152 | 0.78 | DDB1 (0.50) | DDB1CRBNALDH1A1HPGDHSD17B10 | |
| SCHEMBL2329301 | 0.73 | DDB1 (0.54) | DDB1CRBNALDH1A1HPGDHSD17B10 | |
| SCHEMBL4132442 | 0.71 | DDB1 (0.53) | DDB1CRBNALDH1A1HPGDHSD17B10 | |
| SCHEMBL15874850 | 0.71 | DDB1 (0.53) | DDB1CRBNALDH1A1HPGDHSD17B10 | |
| SCHEMBL24815345 | 0.71 | DDB1 (0.53) | DDB1CRBNALDH1A1HPGDHSD17B10 | |
| SCHEMBL29973239 | 0.71 | DDB1 (0.53) | DDB1CRBNALDH1A1HPGDHSD17B10 | |
| SCHEMBL11099324 | 0.70 | SRD5A1 (0.38) | ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL11206268 | 0.70 | DDB1 (0.47) | DDB1CRBNALDH1A1HPGDKDM4E | |
| SCHEMBL7876855 | 0.69 | DDB1 (0.43) | DDB1CRBNHTR2C | |
| SCHEMBL8018754 | 0.67 | ALDH1A1 (0.45) | CRBNALDH1A1KDM4ETSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1014973-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2000-09-20 | — | — | EP | disclosed |
| EP-1014973-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-07-05 | — | — | EP | disclosed |
| EP-1003511-A1 | ALPHA 1aADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-31 | — | — | EP | disclosed |
| US-6057350-A | Alpha 1a adrenergic receptor antagonists | MERCK & CO., INC. (US) | 2000-05-02 | — | — | US | disclosed |
| WO-1998057639-A1 | ALPHA 1aADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |
| WO-1998057632-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |