Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4475932 | 0.86 | GPR84 (0.62) | ALDH1A1CYP1A2CYP2C19GPR84NR4A2 | |
| SCHEMBL7262267 | 0.78 | ALDH1A1 (0.54) | ALDH1A1CYP1A2CYP2C19GPR84NR4A2 | |
| SCHEMBL21158551 | 0.78 | ALDH1A1 (0.54) | ALDH1A1CYP1A2CYP2C19GPR84NR4A2 | |
| SCHEMBL11097545 | 0.78 | ALDH1A1 (0.80) | ALDH1A1CYP1A2CYP2C19GPR84NR4A2 | |
| SCHEMBL18392172 | 0.77 | PDE4B (0.59) | ALDH1A1CYP1A2CYP2C19GPR84NR4A2 | |
| SCHEMBL5327318 | 0.77 | ALDH1A1 (0.52) | ALDH1A1CYP1A2CYP2C19GPR84NR4A2 | |
| SCHEMBL2053494 | 0.77 | HTT (0.70) | ALDH1A1CYP1A2CYP2C19NR4A2LMNA | |
| SCHEMBL18392182 | 0.77 | PDE4B (0.52) | ALDH1A1CYP1A2CYP2C19GPR84NR4A2 | |
| SCHEMBL6786495 | 0.77 | KDM4E (0.50) | ALDH1A1LMNASMN1; SMN2KDM4EHPGD | |
| SCHEMBL7262282 | 0.76 | ABCG2 (0.55) | ALDH1A1CYP1A2CYP2C19GPR84NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166031-A | Substituted tetralins, chromans and related compounds in the treatment of asthma | PFIZER INC, (US) | 2000-12-26 | — | — | US | disclosed |
| EP-0313295-B1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| WO-1989003681-A1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA | PFIZER INC. (US) | 1989-05-05 | — | — | WO | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |
| EP-0313296-A2 | Substituted chromans and related compounds in the treatment of asthma | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |