Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27509094 | 0.85 | MTNR1A (0.44) | KDM4EMAPK1POLBGRIN2DGRIN3B | |
| SCHEMBL2063876 | 0.83 | CTSV (0.64) | POLBALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL19147143 | 0.81 | KDM4E (0.51) | KDM4EMAPK1POLBGRIN2DGRIN3B | |
| SCHEMBL2749368 | 0.79 | KDM4E (0.50) | KDM4EMAPK1POLBGRIN2DGRIN3B | |
| SCHEMBL6783400 | 0.79 | KDM4E (0.50) | KDM4EMAPK1POLBGRIN2DGRIN3B | |
| SCHEMBL256579 | 0.79 | KDM4E (0.50) | KDM4EMAPK1POLBGRIN2DGRIN3B | |
| SCHEMBL8029115 | 0.77 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL7282665 | 0.76 | MTNR1A (0.53) | KDM4EMAPK1POLBGRIN2DGRIN3B | |
| SCHEMBL4765036 | 0.76 | KDM4E (0.47) | KDM4EMAPK1POLBGRIN2DGRIN3B | |
| SCHEMBL9424983 | 0.76 | KDM4E (0.64) | KDM4EMAPK1POLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6809106-B1 | ANTIPROLIFERATION AGENTS; SUCH AS 4-(2-METHOXYPHENOXY)-ANILINO-3-CHLORO-6,7-DIMETHOXYQUINOLINE | ASTRAZENECA AB (SE) | 2004-10-26 | — | — | US | disclosed |
| EP-1178966-B1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2003-10-22 | — | — | EP | disclosed |
| EP-1178966-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | AstraZeneca AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000068200-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2000-11-16 | — | — | WO | disclosed |