SCHEMBL8029142

SCHEMBL8029142

COCC(=O)Nc1cccc2c(O)c(Cl)ccc12

nearest known ligand 0.62

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.51
▸ ALDH1A1 P00352 4/20 0.50
▸ POLB P06746 2/20 0.50
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ LMNA P02545 1/20 0.47
▸ GAA P10253 1/20 0.47
▸ KDM4E B2RXH2 1/20 0.45
▸ HSD17B10 Q99714 1/20 0.45
▸ HPGD P15428 3/20 0.44
▸ NPC1 O15118 3/20 0.44
▸ RAB9A P51151 3/20 0.44
▸ HTT P42858 1/20 0.43
▸ CYP1A2 P05177 1/20 0.43
▸ CYP2C19 P33261 1/20 0.43
▸ TRPV1 Q8NER1 1/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ RECQL P46063 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8029712 0.83 MEN1 (0.45) TSHRALDH1A1POLBSMN1; SMN2LMNA
SCHEMBL8033134 0.82 GABRP (0.44) ALDH1A1POLBSMN1; SMN2LMNAKDM4E
SCHEMBL8032577 0.81 TSHR (0.58) TSHRALDH1A1POLBGAAKDM4E
SCHEMBL5351442 0.80 PARP14 (0.54) ALDH1A1POLBSMN1; SMN2KDM4EHPGD
SCHEMBL20498063 0.78 TRPV1 (0.49) ALDH1A1GAAKDM4EHSD17B10HPGD
SCHEMBL8026737 0.77 TSHR (0.47) TSHRALDH1A1POLBSMN1; SMN2LMNA
SCHEMBL8016617 0.77 TRPV1 (0.43) ALDH1A1POLBSMN1; SMN2LMNAGAA
SCHEMBL29151538 0.77 CYP2C19 (0.68) TSHRALDH1A1POLBGAAKDM4E
SCHEMBL19388071 0.76 POLB (0.68) TSHRALDH1A1POLBSMN1; SMN2LMNA
SCHEMBL20498221 0.76 HSP90AA1 (0.47) ALDH1A1POLBLMNAHPGDTRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0603954-B1 Immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer JOHNSON & JOHNSON CLIN DIAG (US) 2000-03-08 — — EP disclosed
EP-0603953-B1 Use of 4' of 5'-hydroxy and 4'- or 5'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods JOHNSON & JOHNSON CLIN DIAG (US) 1999-02-17 — — EP disclosed
US-5736335-A Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents EASTMAN KODAK COMPANY (US) 1998-04-07 — — US disclosed
US-5641635-A Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents EASTMAN KODAK COMPANY (US) 1997-06-24 — — US disclosed
US-5372931-A Use of 4'-hydroxy- and 4'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods EASTMAN KODAK COMPANY (US) 1994-12-13 — — US disclosed
US-5372932-A Peroxidase-labeled immunoreactant; stabiliztion with a 4-hydroxy or 4-alkoxyarylacetamide EASTMAN KODAK COMPANY (US) 1994-12-13 — — US disclosed
EP-0603953-A1 Use of 4' of 5'-hydroxy and 4'- or 5'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-06-29 — — EP disclosed
EP-0603954-A2 Analytical element and immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-06-29 — — EP disclosed
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