SCHEMBL8029712

SCHEMBL8029712

O=C(CO)Nc1cccc2c(O)c(Cl)ccc12

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 3/20 0.45
▸ KMT2A Q03164 3/20 0.45
▸ ALDH1A1 P00352 5/20 0.44
▸ POLB P06746 2/20 0.44
▸ TRPV1 Q8NER1 5/20 0.43
▸ MAPT P10636 2/20 0.41
▸ KDM4E B2RXH2 1/20 0.41
▸ CLK1 P49759 1/20 0.41
▸ HTT P42858 2/20 0.40
▸ LMNA P02545 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ USP2 O75604 1/20 0.40
▸ TSHR P16473 1/20 0.40
▸ P2RX7 Q99572 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ PARP14 Q460N5 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8033134 0.87 GABRP (0.44) MEN1KMT2AALDH1A1POLBTRPV1
SCHEMBL8029142 0.83 TSHR (0.51) ALDH1A1POLBTRPV1KDM4EHTT
SCHEMBL20498063 0.83 TRPV1 (0.49) MEN1KMT2AALDH1A1TRPV1MAPT
SCHEMBL5351442 0.81 PARP14 (0.54) MEN1KMT2AALDH1A1POLBTRPV1
SCHEMBL8030148 0.79 ALDH1A1 (0.56) MEN1KMT2AALDH1A1POLBTRPV1
SCHEMBL8017543 0.79 HPRT1 (0.50) MEN1KMT2AALDH1A1TRPV1MAPT
SCHEMBL8016617 0.79 TRPV1 (0.43) MEN1KMT2AALDH1A1POLBTRPV1
SCHEMBL20498221 0.74 HSP90AA1 (0.47) MEN1KMT2AALDH1A1POLBTRPV1
SCHEMBL6290020 0.74 MAPT (0.70) MEN1KMT2AALDH1A1POLBMAPT
SCHEMBL6072206 0.73 KMT2A (0.70) MEN1KMT2AALDH1A1POLBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0603954-B1 Immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer JOHNSON & JOHNSON CLIN DIAG (US) 2000-03-08 — — EP disclosed
EP-0603953-B1 Use of 4' of 5'-hydroxy and 4'- or 5'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods JOHNSON & JOHNSON CLIN DIAG (US) 1999-02-17 — — EP disclosed
US-5736335-A Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents EASTMAN KODAK COMPANY (US) 1998-04-07 — — US disclosed
US-5641635-A Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents EASTMAN KODAK COMPANY (US) 1997-06-24 — — US disclosed
US-5372931-A Use of 4'-hydroxy- and 4'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods EASTMAN KODAK COMPANY (US) 1994-12-13 — — US disclosed
US-5372932-A Peroxidase-labeled immunoreactant; stabiliztion with a 4-hydroxy or 4-alkoxyarylacetamide EASTMAN KODAK COMPANY (US) 1994-12-13 — — US disclosed
EP-0603953-A1 Use of 4' of 5'-hydroxy and 4'- or 5'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-06-29 — — EP disclosed
EP-0603954-A2 Analytical element and immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-06-29 — — EP disclosed
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