SCHEMBL8029180

SCHEMBL8029180

CCCN(c1ccc(N)cc1)[Si](OC)(OC)OC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 6/20 0.42
CYP3A4 P08684 5/20 0.42
ALDH1A1 P00352 5/20 0.42
MAPK1 P28482 3/20 0.42
TSHR P16473 3/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
PSMD14 O00487 1/20 0.42
RECQL P46063 1/20 0.42
GFER P55789 1/20 0.42
TP53 P04637 1/20 0.38
ALOX15 P16050 1/20 0.38
MAPT P10636 2/20 0.36
CYP2D6 P10635 3/20 0.35
CYP1A2 P05177 2/20 0.35
KDM4E B2RXH2 2/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
LMNA P02545 2/20 0.32
DRD3 P35462 2/20 0.32
CHRM2 P08172 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3356560 0.81 TP53 (0.37) TP53MAPTDRD3
SCHEMBL5718572 0.79 TDP1 (0.47) TDP1CYP3A4ALDH1A1MAPK1TSHR
Hydrochloric Acid SCHEMBL6048019 0.78 TDP1 (0.45) TDP1CYP3A4ALDH1A1MAPK1TSHR
SCHEMBL33801 0.70 TDP1 (0.67) TDP1CYP3A4ALDH1A1MAPK1TSHR
SCHEMBL5685305 0.70 TDP1 (0.54) TDP1CYP3A4ALDH1A1MAPK1TSHR
SCHEMBL1924408 0.69 TDP1 (0.52) TDP1CYP3A4ALDH1A1MAPK1TSHR
SCHEMBL16391104 0.68 CYP3A4 (0.52) TDP1CYP3A4ALDH1A1MAPK1TSHR
SCHEMBL4193147 0.67 CYP3A4 (0.50) TDP1CYP3A4ALDH1A1MAPK1TSHR
SCHEMBL7520164 0.67 ALDH1A1 (0.75) TDP1CYP3A4ALDH1A1MAPK1TSHR
SCHEMBL6707411 0.67 TDP1 (0.41) TDP1CYP3A4ALDH1A1MAPK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0368279-B1 Silane coupling agent and glass fiber product for laminates NITTO BOSEKI CO LTD (JP) 2000-03-15 EP disclosed
US-5149839-A Improved impregnation, solvent resistance, heat resistance and low water absoprtion properties NITTO BOSEKI CO., LTD. (JP) 1992-09-22 US disclosed
US-5069971-A With epoxy resins, printed circuits, diaminoalklyalkoxysilane NITTO BOSEKI CO., LTD. (JP) 1991-12-03 US disclosed
EP-0368279-A1 Silane coupling agent and glass fiber product for laminates NITTO BOSEKI CO., LTD. (JP) 1990-05-16 EP disclosed