Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857725 | 0.81 | HPGD (0.62) | HPGDSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL16464368 | 0.79 | ALDH1A1 (0.48) | POLBGAAHPGDHTTKMT2A | |
| SCHEMBL5761859 | 0.78 | ALDH1A1 (0.60) | POLBGAAHPGDSMN1; SMN2HTT | |
| SCHEMBL1879993 | 0.77 | MAP2K1 (0.46) | GAASMN1; SMN2HTTALDH1A1KDM4E | |
| SCHEMBL13298472 | 0.77 | ALDH1A1 (0.53) | POLBGAAHPGDSMN1; SMN2HTT | |
| SCHEMBL25206705 | 0.75 | ALOX15 (0.53) | POLBGAAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL259189 | 0.74 | MAPT (0.71) | GAAHPGDSMN1; SMN2HTTKMT2A | |
| SCHEMBL16464155 | 0.73 | HTR6 (0.51) | POLBGAAHPGDSMN1; SMN2HTT | |
| SCHEMBL6102612 | 0.72 | GRIN2D (0.61) | HPGDALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL30532593 | 0.72 | SMN1; SMN2 (0.58) | POLBGAAHPGDSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6075037-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-13 | — | — | US | disclosed |
| EP-0763035-A4 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1997-10-01 | — | — | EP | disclosed |
| EP-0763035-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995033748-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-12-14 | — | — | WO | disclosed |