Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.56 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029636 | 0.82 | SIGMAR1 (0.59) | SIGMAR1ALDH1A1LMNADRD4KDM4E | |
| SCHEMBL8029595 | 0.80 | LMNA (0.53) | SIGMAR1TRPV4ALDH1A1LMNAHTT | |
| SCHEMBL8020121 | 0.78 | SIGMAR1 (0.56) | SIGMAR1ALDH1A1LMNADRD4KDM4E | |
| SCHEMBL8035809 | 0.73 | SIGMAR1 (0.53) | SIGMAR1TRPV4ALDH1A1LMNAHTT | |
| SCHEMBL8033296 | 0.72 | SIGMAR1 (0.52) | SIGMAR1ALDH1A1DRD4KDM4EMC4R | |
| SCHEMBL8035713 | 0.72 | MAPK1 (0.57) | SIGMAR1ALDH1A1LMNAHTTDRD4 | |
| SCHEMBL13036529 | 0.71 | SIGMAR1 (0.69) | SIGMAR1ALDH1A1LMNADRD4KDM4E | |
| SCHEMBL8020027 | 0.71 | SIGMAR1 (0.55) | SIGMAR1ALDH1A1HTTKDM4EMAPT | |
| SCHEMBL18177902 | 0.71 | CYP2D6 (0.73) | ALDH1A1LMNAHTT | |
| SCHEMBL8033351 | 0.70 | SIGMAR1 (0.68) | SIGMAR1ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702010-B1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-15 | — | — | EP | disclosed |
| US-5691340-A | CENTRAL NERVOUS SYSTEM DISORDERS, STROKES, CARDIOVASCULAR DISORDERS, ALZHEIMER*S DISEASE OR ANTIINFLAMMATORY AGENTS | ADIR ET COMPAGNIE (FR) | 1997-11-25 | — | — | US | disclosed |
| US-5668138-A | AFFINITY FOR SIGMA RECEPTORS, CENTRAL NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-09-16 | — | — | US | disclosed |
| EP-0702010-A1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-03-20 | — | — | EP | disclosed |