Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.53 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8020090 | 0.80 | SIGMAR1 (0.42) | SIGMAR1ALDH1A1LMNAHTTDRD4 | |
| SCHEMBL8031455 | 0.79 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1LMNAHTTDRD4 | |
| SCHEMBL8035752 | 0.79 | PPARA (0.55) | SIGMAR1TRPV4PPARAALDH1A1LMNA | |
| SCHEMBL8033268 | 0.77 | KDM4E (0.45) | ALDH1A1HTTBCHEACHEDRD4 | |
| SCHEMBL18177902 | 0.76 | CYP2D6 (0.73) | ALDH1A1LMNAHTTKMT2ACYP1A2 | |
| SCHEMBL8020085 | 0.75 | LMNA (0.59) | SIGMAR1ALDH1A1LMNAACHEBACE1 | |
| SCHEMBL8029654 | 0.74 | IGF1R (0.55) | SIGMAR1ALDH1A1LMNAHTTKDM4E | |
| SCHEMBL5752956 | 0.74 | KDM4E (0.54) | SIGMAR1ALDH1A1HTTKDM4EKMT2A | |
| SCHEMBL8029891 | 0.74 | SIGMAR1 (0.50) | SIGMAR1ALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL8029632 | 0.73 | SIGMAR1 (0.56) | SIGMAR1TRPV4ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702010-B1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-15 | — | — | EP | disclosed |
| US-5691340-A | CENTRAL NERVOUS SYSTEM DISORDERS, STROKES, CARDIOVASCULAR DISORDERS, ALZHEIMER*S DISEASE OR ANTIINFLAMMATORY AGENTS | ADIR ET COMPAGNIE (FR) | 1997-11-25 | — | — | US | disclosed |
| US-5668138-A | AFFINITY FOR SIGMA RECEPTORS, CENTRAL NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-09-16 | — | — | US | disclosed |
| EP-0702010-A1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-03-20 | — | — | EP | disclosed |