Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 14/20 | 0.53 |
| ▸ | EDNRA | P25101 | 13/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042973 | 0.90 | EDNRB (0.66) | EDNRBEDNRA | |
| SCHEMBL8900951 | 0.86 | EDNRB (0.64) | EDNRBEDNRALMNAMAPTHPGD | |
| SCHEMBL8901534 | 0.81 | EDNRB (0.69) | EDNRBEDNRA | |
| SCHEMBL8902335 | 0.76 | EDNRB (0.80) | EDNRBEDNRA | |
| SCHEMBL8039429 | 0.74 | EDNRA (0.55) | EDNRBEDNRA | |
| SCHEMBL8041521 | 0.73 | EDNRB (0.51) | EDNRBEDNRA | |
| SCHEMBL4712914 | 0.72 | MAPK8 (0.70) | EDNRBEDNRALMNASMN1; SMN2 | |
| SCHEMBL8900846 | 0.70 | EDNRA (0.81) | EDNRBEDNRA | |
| SCHEMBL3956234 | 0.70 | MAPT (0.49) | PTGDR2LMNAMAPTHPGD | |
| SCHEMBL6322272 | 0.70 | EDNRB (0.64) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6075037-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-13 | — | — | US | disclosed |