Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 17/20 | 0.64 |
| ▸ | EDNRA | P25101 | 15/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8901534 | 0.95 | EDNRB (0.69) | EDNRBEDNRA | |
| SCHEMBL8902335 | 0.89 | EDNRB (0.80) | EDNRBEDNRA | |
| SCHEMBL8029697 | 0.86 | EDNRB (0.53) | EDNRBEDNRALMNAMAPTHPGD | |
| SCHEMBL8900846 | 0.84 | EDNRA (0.81) | EDNRBEDNRA | |
| SCHEMBL6859336 | 0.83 | PPARG (0.54) | EDNRBEDNRALMNAMAPT | |
| SCHEMBL6857727 | 0.80 | PPARG (0.72) | MAPTSMN1; SMN2 | |
| SCHEMBL6851257 | 0.80 | PLA2G2A (0.53) | EDNRBEDNRAMAPT | |
| SCHEMBL6858332 | 0.79 | PPARG (0.50) | EDNRBEDNRALMNAMAPT | |
| SCHEMBL6851276 | 0.78 | EDNRB (0.52) | EDNRBEDNRAMAPT | |
| SCHEMBL6322272 | 0.78 | EDNRB (0.64) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686481-A | INDOLE DERIVATIVES; TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0676959-A4 | ENDOTHELIN RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM CORP (US) | 1996-01-03 | — | — | EP | disclosed |
| EP-0676959-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-18 | — | — | EP | disclosed |
| WO-1994014434-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-07 | — | — | WO | disclosed |