SCHEMBL8030049

SCHEMBL8030049

CC(=O)Nc1ccc2c(C#N)c(O)c(C#N)cc2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.50
▸ KMT2A Q03164 4/20 0.40
▸ MEN1 O00255 3/20 0.40
▸ MAPT P10636 3/20 0.40
▸ KDM4E B2RXH2 2/20 0.40
▸ NPC1 O15118 2/20 0.40
▸ RAB9A P51151 2/20 0.40
▸ GLA P06280 1/20 0.40
▸ TNNI3 P19429 1/20 0.40
▸ TNNT2 P45379 1/20 0.40
▸ TNNC1 P63316 1/20 0.40
▸ RUNX1 Q01196 1/20 0.40
▸ CBFB Q13951 1/20 0.40
▸ PFKFB1 P16118 1/20 0.40
▸ CA12 O43570 1/20 0.39
▸ BRD4 O60885 1/20 0.39
▸ NR1I2 O75469 1/20 0.39
▸ CA1 P00915 1/20 0.39
▸ CA2 P00918 1/20 0.39
▸ MB P02144 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8028468 0.81 ESR1 (0.51) ALDH1A1KMT2AMEN1MAPTKDM4E
SCHEMBL5754358 0.76 ALDH1A1 (0.54) ALDH1A1KMT2AMEN1MAPTKDM4E
SCHEMBL7751135 0.74 ALDH1A1 (0.57) ALDH1A1KMT2AMEN1MAPTKDM4E
SCHEMBL7754593 0.73 ALDH1A1 (0.65) ALDH1A1KMT2AMEN1MAPTKDM4E
SCHEMBL8351343 0.73 ALDH1A1 (0.79) ALDH1A1KMT2AMEN1MAPTKDM4E
SCHEMBL13414550 0.70 ALDH1A1 (0.65) ALDH1A1KMT2AMEN1MAPTKDM4E
SCHEMBL29588415 0.70 ALDH1A1 (0.65) ALDH1A1KMT2AMEN1MAPTKDM4E
SCHEMBL22078587 0.70 ALDH1A1 (0.65) ALDH1A1KMT2AMEN1MAPTKDM4E
SCHEMBL22626109 0.70 ALDH1A1 (0.65) ALDH1A1KMT2AMEN1MAPTKDM4E
SCHEMBL3466850 0.69 EGFR (0.50) ALDH1A1KMT2AMEN1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0603954-B1 Immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer JOHNSON & JOHNSON CLIN DIAG (US) 2000-03-08 — — EP disclosed
EP-0603953-B1 Use of 4' of 5'-hydroxy and 4'- or 5'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods JOHNSON & JOHNSON CLIN DIAG (US) 1999-02-17 — — EP disclosed
US-5736335-A Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents EASTMAN KODAK COMPANY (US) 1998-04-07 — — US disclosed
US-5641635-A Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents EASTMAN KODAK COMPANY (US) 1997-06-24 — — US disclosed
US-5372931-A Use of 4'-hydroxy- and 4'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods EASTMAN KODAK COMPANY (US) 1994-12-13 — — US disclosed
US-5372932-A Peroxidase-labeled immunoreactant; stabiliztion with a 4-hydroxy or 4-alkoxyarylacetamide EASTMAN KODAK COMPANY (US) 1994-12-13 — — US disclosed
EP-0603953-A1 Use of 4' of 5'-hydroxy and 4'- or 5'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-06-29 — — EP disclosed
EP-0603954-A2 Analytical element and immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-06-29 — — EP disclosed
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