SCHEMBL7754593

SCHEMBL7754593

CC(=O)Nc1ccc(O)c(C#N)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.65
PKM P14618 1/20 0.50
SMN1; SMN2 Q16637 3/20 0.49
KMT2A Q03164 4/20 0.48
MEN1 O00255 3/20 0.48
MAPT P10636 2/20 0.48
CA12 O43570 1/20 0.48
BRD4 O60885 1/20 0.48
NR1I2 O75469 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
MB P02144 1/20 0.48
CYP1A1 P04798 1/20 0.48
CA3 P07451 1/20 0.48
CYP3A4 P08684 1/20 0.48
RARG P13631 1/20 0.48
TSHR P16473 1/20 0.48
ALOX5AP P20292 1/20 0.48
CA4 P22748 1/20 0.48
CA7 P43166 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8351343 0.86 ALDH1A1 (0.79) ALDH1A1SMN1; SMN2KMT2AMEN1MAPT
SCHEMBL2169524 0.84 PKM (0.51) ALDH1A1PKMSMN1; SMN2KMT2AMEN1
SCHEMBL22078587 0.83 ALDH1A1 (0.65) ALDH1A1PKMSMN1; SMN2KMT2AMEN1
SCHEMBL11209050 0.82 CYP3A4 (0.51) ALDH1A1SMN1; SMN2KMT2AMEN1MAPT
SCHEMBL11297032 0.82 KMT2A (0.49) ALDH1A1SMN1; SMN2KMT2AMEN1MAPT
SCHEMBL6815182 0.81 ALDH1A1 (0.63) ALDH1A1SMN1; SMN2KMT2AMEN1MAPT
SCHEMBL3554749 0.81 ALDH1A1 (0.63) ALDH1A1SMN1; SMN2KMT2AMEN1MAPT
SCHEMBL849569 0.81 ALDH1A1 (0.63) ALDH1A1SMN1; SMN2KMT2AMEN1MAPT
SCHEMBL1192659 0.81 ALDH1A1 (0.63) ALDH1A1SMN1; SMN2KMT2APLA2G7
SCHEMBL12248249 0.81 ALDH1A1 (0.63) ALDH1A1SMN1; SMN2KMT2AMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0704539-B1 Chemiluminescent reagent and assay using a substituted acetanilide for light generation JOHNSON & JOHNSON CLIN DIAG (US) 2001-02-28 EP disclosed
EP-0603954-B1 Immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer JOHNSON & JOHNSON CLIN DIAG (US) 2000-03-08 EP disclosed
EP-0603953-B1 Use of 4' of 5'-hydroxy and 4'- or 5'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods JOHNSON & JOHNSON CLIN DIAG (US) 1999-02-17 EP disclosed
US-5736335-A Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents EASTMAN KODAK COMPANY (US) 1998-04-07 US disclosed
US-5705357-A DETECTING PEROXIDASE; SENSITIVITY, LOW BACKGROUND; MEDICAL DIAGNOSIS JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC. (US) 1998-01-06 US disclosed
US-5641635-A Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents EASTMAN KODAK COMPANY (US) 1997-06-24 US disclosed
EP-0704539-A2 Chemiluminescent reagent and assay using a substituted acetanilide for light generation JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC. (US) 1996-04-03 EP disclosed
US-5372931-A Use of 4'-hydroxy- and 4'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods EASTMAN KODAK COMPANY (US) 1994-12-13 US disclosed
US-5372932-A Peroxidase-labeled immunoreactant; stabiliztion with a 4-hydroxy or 4-alkoxyarylacetamide EASTMAN KODAK COMPANY (US) 1994-12-13 US disclosed
EP-0603953-A1 Use of 4' of 5'-hydroxy and 4'- or 5'-alkoxy-substituted electron transfer agents in compositions, elements, test kits and analytical methods Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-06-29 EP disclosed
EP-0603954-A2 Analytical element and immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-06-29 EP disclosed