Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | FABP7 | O15540 | 1/20 | 0.45 |
| ▸ | FABP3 | P05413 | 1/20 | 0.45 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14503720 | 0.81 | TTK (0.48) | ALDH1A1POLBHPGDTTK | |
| SCHEMBL31347620 | 0.80 | ALDH1A1 (0.58) | ALDH1A1MAPTHPGDHTTKMT2A | |
| SCHEMBL14209970 | 0.80 | ALDH1A1 (0.58) | ALDH1A1MAPTHPGDHTTKMT2A | |
| SCHEMBL29963136 | 0.78 | HSD17B1 (0.76) | ALDH1A1HSD17B1HSD17B2HSD17B10CYP1A2 | |
| SCHEMBL11900180 | 0.78 | CASP6 (0.68) | ALDH1A1HSD17B1HSD17B2HSD17B10CYP1A2 | |
| SCHEMBL19355161 | 0.78 | HSD17B1 (0.55) | ALDH1A1HSD17B1HSD17B2HSD17B10CYP1A2 | |
| SCHEMBL1122275 | 0.78 | HSD17B1 (0.76) | ALDH1A1HSD17B1HSD17B2HSD17B10CYP1A2 | |
| SCHEMBL1807568 | 0.78 | HSD17B1 (0.55) | ALDH1A1HSD17B1HSD17B2HSD17B10CYP1A2 | |
| SCHEMBL6746166 | 0.76 | MAPT (0.62) | ALDH1A1HSD17B1HSD17B2CYP1A2POLB | |
| SCHEMBL8030049 | 0.76 | ALDH1A1 (0.50) | ALDH1A1HSD17B1HSD17B2PLA2G7HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053108-B2 | Indoline compounds | LES LABORATOIRES SERVIER (FR) | 2006-05-30 | — | — | US | disclosed |
| EP-1348704-B1 | Indole derivatives as 5-HT2C antagonists, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2006-05-17 | — | — | EP | disclosed |
| US-6998403-B2 | Benzoindoline compounds | LES LABORATOIRES SERVIER (FR) | 2006-02-14 | — | — | US | disclosed |
| EP-1516871-A1 | Benzoindoline derivatives with adrenergic activity | Les Laboratoires Servier (FR) | 2005-03-23 | — | — | EP | disclosed |
| US-20050059675-A1 | Antidepressants; N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-1,2-dihydro-3H-benzo[e]indole-3-carboxamide; antagonist of adrenergic receptor, serotonin receptor; anxiety, schizophrenia, Parkinson's disease, cognitive disorders, schizophrenia | LES LABORATOIRES SERVIER (FR) | 2005-03-17 | — | — | US | disclosed |
| US-20040192736-A1 | New indoline compounds | LAVIELLE GILBERT (FR) | 2004-09-30 | — | — | US | disclosed |
| US-6759421-B2 | N-(3-PYRIDYL)-1,2-DIHYDRO-3H-BENZO(E)INDOLE-3-CARBOXAMIDE DERIVATIVES USEFUL AS A 5-HT2C ANTAGONIST | LES LABORATOIRES SERVIER (FR) | 2004-07-06 | — | — | US | disclosed |
| US-20030199555-A1 | Indoline compounds and to pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2003-10-23 | — | — | US | disclosed |
| EP-1348704-A1 | Indole derivatives as 5-HT2C antagonists, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-10-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199555-A1 | Indoline compounds and to pharmaceutical compositions containing them | TPH1, IDO1, HTR3A | ALDH1A1 977/4885HSD17B1 551/4885HSD17B2 439/4885 |
| US-20040192736-A1 | New indoline compounds | TPH1, HTR3A, HTR1D | ALDH1A1 643/4885HSD17B1 397/4885HSD17B2 319/4885 |
| US-20050059675-A1 | Antidepressants; N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-1,2-dihydro-3H-benzo[e]indole-3-carboxamide; antagonist of adrenergic receptor, serotonin receptor; anxiety, schizophrenia, Parkinson's disease, cognitive disorders, schizophrenia | HTR2C, HTR2A, ADRA2C | ALDH1A1 755/4885HSD17B1 550/4885HSD17B2 313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.