SCHEMBL8030141

SCHEMBL8030141

CC(=O)Nc1cc(Cl)c(O)c(Cl)c1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.41
POLB P06746 3/20 0.41
NPC1 O15118 1/20 0.41
MAPT P10636 1/20 0.41
RAB9A P51151 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA9 Q16790 1/20 0.41
HSD17B10 Q99714 4/20 0.40
LMNA P02545 3/20 0.40
KDM4E B2RXH2 2/20 0.40
GAA P10253 3/20 0.40
TDP1 Q9NUW8 1/20 0.40
HPGD P15428 3/20 0.39
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
ALOX15 P16050 2/20 0.38
PGK1 P00558 1/20 0.38
TSHR P16473 2/20 0.38
MAPK1 P28482 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7027625 0.86 ALDH1A1 (0.41) ALDH1A1POLBNPC1MAPTRAB9A
SCHEMBL14606814 0.86 ALDH1A1 (0.41) ALDH1A1POLBNPC1MAPTRAB9A
SCHEMBL14606476 0.85 ALDH1A1 (0.44) ALDH1A1POLBNPC1MAPTRAB9A
SCHEMBL14135427 0.84 ALDH1A1 (0.42) ALDH1A1POLBNPC1MAPTRAB9A
SCHEMBL6814332 0.83 ALDH1A1 (0.56) ALDH1A1POLBMAPTCA1CA2
SCHEMBL14354728 0.79 ALDH1A1 (0.43) ALDH1A1POLBNPC1MAPTRAB9A
SCHEMBL11149691 0.78 HSD17B10 (0.45) ALDH1A1POLBNPC1MAPTRAB9A
SCHEMBL6814336 0.78 LMNA (0.39) ALDH1A1POLBNPC1MAPTRAB9A
SCHEMBL14354727 0.76 GPR35 (0.44) ALDH1A1POLBNPC1MAPTRAB9A
SCHEMBL14625048 0.76 ALDH1A1 (0.40) ALDH1A1POLBNPC1MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5372932-A Peroxidase-labeled immunoreactant; stabiliztion with a 4-hydroxy or 4-alkoxyarylacetamide EASTMAN KODAK COMPANY (US) 1994-12-13 US claimed
EP-0603954-B1 Immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer JOHNSON & JOHNSON CLIN DIAG (US) 2000-03-08 EP disclosed
US-5372932-A Peroxidase-labeled immunoreactant; stabiliztion with a 4-hydroxy or 4-alkoxyarylacetamide EASTMAN KODAK COMPANY (US) 1994-12-13 US disclosed
EP-0603954-A2 Analytical element and immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer Johnson & Johnson Clinical Diagnostics, Inc. (US) 1994-06-29 EP disclosed