Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Methylene Chloride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Chloride SCHEMBL28193861 | 0.96 | — | — | |
| Methylene Chloride SCHEMBL8949658 | 0.96 | CA2 (0.41) | — | |
| Sulfuric Acid SCHEMBL6247161 | 0.82 | — | — | |
| SCHEMBL246838 | 0.82 | CA2 (0.58) | — | |
| SCHEMBL8596055 | 0.82 | CA2 (0.58) | — | |
| SCHEMBL128169 | 0.82 | — | — | |
| SCHEMBL15109974 | 0.82 | — | — | |
| SCHEMBL25599 | 0.82 | CA2 (0.58) | — | |
| SCHEMBL105 | 0.82 | — | — | |
| Methylene Chloride SCHEMBL9185705 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023134465-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF AND USE THEREOF | 上海艾力斯医药科技股份有限公司 | 2023-07-20 | — | — | WO | disclosed |
| EP-3388425-B1 | AMINOAZOLE DERIVATIVE | TEIJIN PHARMA LTD (JP) | 2020-08-05 | — | — | EP | disclosed |
| US-10689354-B2 | Aminoazole derivative | TEIJIN PHARMA LIMITED (JP) | 2020-06-23 | — | — | US | disclosed |
| US-20190031628-A1 | AMINOAZOLE DERIVATIVE | TEIJIN PHARMA LIMITED (JP) | 2019-01-31 | — | — | US | disclosed |
| EP-3388425-A1 | AMINOAZOLE DERIVATIVE | Teijin Pharma Limited (JP) | 2018-10-17 | — | — | EP | disclosed |
| CN-104262290-B | Preparation method of pridinol mesylate | 湖北工业大学 | 2017-01-11 | — | — | CN | disclosed |
| WO-2015085482-A1 | EGFR INHIBITOR FORMS | NOVARTIS AG (CH) | 2015-06-18 | — | — | WO | disclosed |
| WO-2015083059-A1 | FORMS OF THE EGFR INHIBITOR | NOVARTIS AG (CH) | 2015-06-11 | — | — | WO | disclosed |
| WO-2015081463-A1 | EGFR INHIBITOR FORMS | NOVARTIS AG (CH) | 2015-06-11 | — | — | WO | disclosed |
| CN-104262290-A | Preparation method of pridinol mesylate | UNIV HUBEI TECHNOLOGY | 2015-01-07 | — | — | CN | disclosed |
| CN-1127502-C | Paroxetine methanesulfonate | SMITHKLINE BEECHAM PLC (GB) | 2003-11-12 | — | — | CN | disclosed |
| CN-1315949-A | Salts of paroxetine | SMITHKLINE BEECHAM PLC (GB) | 2001-10-03 | — | — | CN | disclosed |
| US-6043387-A | USEFUL AS KEY COMPONENTS IN CATALYSTS FOR ASYMMETRIC REACTIONS, PROVIDING DESIRABLY HIGH ENANTIOMERIC EXCESS | MERCK & CO., INC. (US) | 2000-03-28 | — | — | US | disclosed |
| CN-1182086-A | New bisimide compounds, process for preparing them and pharmaceutical compositions containing them | ADIR (FR) | 1998-05-20 | — | — | CN | disclosed |
| EP-0125053-B1 | PROCESS FOR PREPARING SECONDARY AMINES | SMITHKLINE BECKMAN CORPORATION (US) | 1986-09-17 | — | — | EP | disclosed |
| US-4579972-A | Intermediates for preparing secondary amines | SMITHKLINE BECKMAN CORPORATION (US) | 1986-04-01 | — | — | US | disclosed |
| US-4540819-A | Process for preparing secondary amines | SMITHKLINE BECKMAN CORPORATION (US) | 1985-09-10 | — | — | US | disclosed |
| EP-0125053-A1 | Process for preparing secondary amines | SMITHKLINE BECKMAN CORPORATION (US) | 1984-11-14 | — | — | EP | disclosed |
| US-4426311-A | Methylene chloride-methane sulfonic acid stripping compositions and methods for using same | ALLIED CORPORATION (US) | 1984-01-17 | — | — | US | disclosed |
| EP-0043438-A2 | Methylene chloride-methane sulfonic acid stripping compositions and methods for using same | ALLIED CORPORATION (US) | 1982-01-13 | — | — | EP | disclosed |