Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019842 | 0.88 | POLB (0.39) | POLBALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL8033071 | 0.88 | LMNA (0.39) | POLBALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL8033068 | 0.87 | NPC1 (0.37) | NPC1RAB9ADHODHDPP4 | |
| SCHEMBL8033819 | 0.84 | NPC1 (0.42) | MAPTNPC1RAB9ASMN1; SMN2DHODH | |
| SCHEMBL8035257 | 0.82 | ALDH1A1 (0.43) | POLBALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL8029754 | 0.82 | KCNN4 (0.40) | ALDH1A1MAPTRAB9ASMN1; SMN2DHODH | |
| SCHEMBL13002508 | 0.80 | KMT2A (0.36) | MAPTNPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL13002561 | 0.76 | KCNN4 (0.38) | ALDH1A1MAPTNPC1RAB9ATDP1 | |
| SCHEMBL13059500 | 0.74 | DHODH (0.33) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL14996192 | 0.73 | KCNN4 (0.43) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250157-B1 | NOVEL HETEROCYCLIC COMPOUNDS | PANACEA BIOTEC LTD (IN) | 2014-11-05 | — | — | EP | disclosed |
| US-8455479-B2 | Heterocyclic compounds | PANACEA BIOTEC LIMITED (IN) | 2013-06-04 | — | — | US | disclosed |
| WO-2009093269-A1 | NOVEL HETEROCYCLIC COMPOUNDS | PANACEA BIOTEC LIMITED (IN) | 2009-07-30 | — | — | WO | disclosed |